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“不老神药”雷帕霉素的前世今生
点击次数:555 发布时间:2019-08-27
 

足球竞猜软件    ZAINANTAIPINGYANGDEWANQINGBIBOZHONG,YOUYIZUOGULINGLINGDEXIAODAO,TALINANMEIDALUZHILIYUE3000GONGLI,LITAIPINGYANGSHANGQITADAOYUJULIYEHENYUAN,TAJIUSHISHENMIYOURENDEFUHUOJIEDAO(DANGDICHENG“LAPANUYI DAO” , Rapa Nui)。FUHUOJIEDAOYIQIJUDASHIDIAOXIANGER,DAOSHANGYOUYUE600ZUOYISHANGDEDASHIDIAOXIANG,1964NIAN,JIANADAMAIJIERDAXUEDESITANLI?SIKELINAZAIZHEIZUODAOSHANGCAIJILEYIFENTURANGYANGBEN。SUIHOU,ZAIMENGTELIER,HUISHIDEYANJIUZHECONGZHONGFAXIANLEYOU Streptomyces hygroscopicusBIAODADEYIGEHUAHEWU,KEZUOWEIQIANZAIDEKANGZHENJUNYAOWU,YANJIUZHEGENJUQIFAXIANDIJIANGQIMINGWEILEIPAMEISU(rapamycin)。

    LEIPAMEISU,YOUMINGXILUOMOSI,SHUYUDAHUANNEIZHILEIHUAHEWU。

足球竞猜软件    QICHULEIPAMEISUBEIZUOWEIDIDUXINGDEKANGZHENJUNYAOWU,1977NIAN,RENMENJINGYADEFAXIANGAIYAOWUHAIJUYOUMIANYIYIZHIDEZUOYONG,BINGQIEXIAOGUOXIANZHU。ZHIHOU,LEIPAMEISUZUOWEIKANGJUNJIDEKAIFAZHILUJIUCIZHONGZHI,KEXUEJIAKAISHIZAILINGYILINGYUKAIFATADEYAOYONGQIANLI——qiGUANYIZHI。RUGUOJIASHEYIZHIZHIHOURENTIMIANYIXITONGNENGGOUBAOCHISHOUKONG,XINDEQIGUANJIANGBUHUIBEIPAICHI。LINCHUANGSHIYANZHENGMINGLEZHEIYIGUANDIANDEZHENGQUEXING。1999NIAN,FDAPIZHUNLEIPAMEISUZUOWEIMIANYIYIZHIJIYONGYUSHENYIZHI,SHANGPINMINGWEI“LEIPAMING”。

    LEIPAMEISUJIQIJIEGOU

    20SHIJI80NIANDAI,MEIGUOGUOJIAAIZHENGYANJIUZHONGXIN(NCI)YOUFAXIANXILUOMOSIYOUKANGZHONGLIUZUOYONG。BUGUOQIYAOWUDONGLIXUEXINGNENGBUHAO,SUOYIWEIKAIFAQISHANGSHI。SUIHOUYOUFAXIANTAJUYOUYUFANGGUANZHUANGDONGMAIZAIXIAZHAIYUZHILIAOSHENJINGTUIXINGXINGJIBINGDEZUOYONG。

    20SHIJI90NIANDAI,FAXIANXILUOMOSIYIYIZHIXIBAOSHENGZHANGZHOUQIDEFANGSHIYIZHIZHONGLIUXIBAOFANZHI,YOUCIFAXIANLELEIPAMEISUZUOYONGYUYIZHONGBINGWEICENGBEIBIAOSHIDEDANBAI,BINGJIANGQIMINGMINGWEI“target of rapamycin”,JITONGCHANGSUOSHUODETORDANBAI。HUISHIGONGSIZAIXILUOMOSIJICHUSHANGJINXINGXIUSHI,HECHENGTIXILUOMOSI(temsirolimus,CCI-779),JINYONGYUKANGZHONGLIU。SUIHOUNUOHUAGONGSIJIANGYIWEIMOSI(everolimus,RAD001)TUIXIANGSHICHANG,TAJIKEYIZUOWEIMIANYIYIZHIJIZHILIAOSHENYIZHIHEGANYIZHIDEMIANYIPAIJIFANYING,YOUKEYIZUOWEIKANGZHONGLIUYAOZHILIAOSHENAI、ruXIANAIHEYIXIANAIDENG。

    ZHIHOU,GEKEYANTUANDUIKAISHIKANCHATORDANBAIYUXIBAONEIQITACHENGFENZHIJIANDEXIANGHUZUOYONG,BINGJIESHILEFENZIXINHAOTONGLUZAIJIBINGFAZHANZHONGDEGUANJIANZUOYONG。2006NIAN,PowersDEYANJIUCHENGGUOZHENGSHIDUIJIAOMUJINXINGLEIPAMEISUCHULINENGXIANZHUYANZHANGQISHOUMING。BlackwellDENGRENFAXIANLEIPAMEISUTONGYANGNENGGOUYANZHANGXIULIXIANCHONGDESHOUMING。LEIPAMEISUYIZHITORXINHAOCONGERBUFENJIECHULETORDUIYUBAOSHOUDEZHUANLUYINZIDAF-16/FoxOHESKN-1/NrfDEYIZHIZUOYONG,HUOHUADEDAF-16HESKN-1CANYUDIAOKONGXIANCHONGDUIHUANJING、DAIXIEHEDANBAIDUXINGYALIDEXIANGYING,YOUZHUYUSHENGWUTISHOUMINGDEYANZHANG。

    ZHEIYIFAXIANZHENGMINGLETORDANBAISHIKONGZHIXIBAOXINCHENDAIXIEHESHENGZHANGDEZONGKAIGUAN。

足球竞猜软件    YUSHI,KEXUEJIAMENKAISHIYANJIULEIPAMEISUDEQITAYONGTU,YOUQISHIDUIYUAIZHENGDEZHILIAO。2007NIANQI,LEIPAMEISUDELIANGZHONGYANSHENGWUKAIFAYONGYUZHILIAOAIZHENG,FENBIEWEIHUIRUIGONGSIDETANLUOMOSIHENUOHUAGONGSIDEYIWEISI。

    ZAI2009NIAN,NatureZAZHISHANGDEYIPIANBAODAOYINQIRENMENDEGUANGFANGUANZHU,KEXUEJIAMENFAXIANLEIPAMEISUKEYIYANZHANGCIXINGXIAOSHUDESHOUMINGYUE15%,XIONGXINGXIAOSHUSHOUYUE10%。HarrisonDENGRENZAILAOSHUCHUSHENGHOUDEDI600TIANKAISHIWEISHILEIPAMEISU,JIEGUOFAXIANXIANGBIYUDUIZHAOZU,LEIPAMEISUCHULIZUXIAOSHUDESHOUMINGYOULEXIANZHUDEZENGJIA,YANHUANLESHUAILAODEJINCHENG。SciencePINGJIACHENG:“ZHEIYIYANJIUZHENGMINGLEYAOWUKEYIYANZHANGBURUDONGWUDESHOUMING”。CONGCIZHIHOU,LEIPAMEISUCHENGWEISHUAILAOSHENGWUXUELINGYUZHONGDEMINGXINGHUAHEWU。

    TORDANBAISHIDANGJINLAONIANYIXUEHEYAOXUEDEZHONGDIANGUANZHUDUIXIANG

足球竞猜软件    YINWEIYUELAIYUEDUODEDONGWUJILINCHUANGSHIYANBIAOMING,YIZHIBURUDONGWUXIBAOZHONGDETORDANBAIDEHUOXING,NENGJIANGDIDUOSHULAONIANXIANGGUANJIBINGDEFABINGFENGXIAN,BIRUAIZHENG、AERCIHAIMOBING、PAJINSENBING、XINJITUIXINGXINGBINGBIAN、ⅡXINGTANGNIAOBING、GUZHISHUSONG、HUANGBANBIANXINGDENG。ZHEIYESHIDELEIPAMEISUKENENGZHENZHENGCHENGWEILISHISHANGZHONGDUODIWANGZHENGXIANGZHUIZHUDE“ZHANGSHOUYAO”。

足球竞猜软件    LEIPAMEISUSHIFOUTONGYANGSHIHEYONGYUYANHUANRENLEIDESHUAILAO?

足球竞猜软件    DEKESASIDAXUEDEDean KelloggJIQITONGSHIJI80-90SUIDELAORENFUYONGLEBANJILIANG(XIANGDANGYUJIESHOUYIZHIBINGRENFUYONGJILIANGDEYIBAN)DELEIPAMEISUGONG16ZHOU,FAXIANJINYOUYILIBIAOXIANCHUFUZUOYONG。GENGLINGRENXINWEIDESHI,SUIZHESHIYANDETUIJIN,BEISHIZHEDEXINGZOUNENGLIDEDAOLEHENDADEGAISHAN。KelloggRENWEI,LEIPAMEISUYOUCHAOYIRIKENENGBEIYINGYONGYUYANHUANRENLEIDESHUAILAO

    CIWAI,MEIGUOGUOLIWEISHENGYANJIUYUAN(NIH)YUANZHANGFrancis CollinsJIAOSHOUYU2011NIANFABIAOZAIScience Translational MedicineSHANGDEYANJIUJIEGUOXIANSHI:DUIERTONGZAOSHUAIZHENG(HGPS)BINGRENDECHENGXIANWEIXIBAOJINXINGDIJILIANGDELEIPAMEISUCHULI,KEYIYOUDAOXIBAOTONGGUOZISHIZUOYONGQINGCHUCUOWUZHEDIEDEDANBAIZHI,CONGERXIANZHUYANZHANGXIBAODE“SHOUMING”。CollinsJIAOSHOUZHICHULEIPAMEISUHENKENENGWEIZAOSHUAIZHENGERTONGDAILAIFUYIN。SUIRANYOUHENDUODEYANJIUZHEDOUDUILEIPAMEISUCHIYOUJIJIDETAIDU,DANYEYOUBUSHAORENDUIQIANQUANXINGBIAOSHIDANYOU。

    2013NIANScienceDEBAODAOZHICHU,FUYONGLEIPAMEISUDEHUANZHEHUICHANSHENGYIDAOSUDIKANGDENGFUZUOYONG,DANZHEIXIEFUZUOYONGDADUOSHIZAIqiGUANYIZHIDEBINGRENZHONGFAXIANDE,KENENGBUJUYOUDAIBIAOXING。GUANYULEIPAMEISUZAIJIANKANGRENQUNYOUQISHILAONIANRENZHONGDEZUOYONG,MUQIANHAIQUEFAZUGOUDESHIYANZHENGJU。MEIGUONANJIAZHOUDAXUEJIAOSHOUValter LongoYEZHICHU,“SUIRANLEIPAMEISUZAISHIYANZHONGNENGYANZHANGSHOUMING,DANSHIQIZUOYONGDETONGLUYECANYUXIBAOZHENGCHANGGONGNENGDEDIAOKONG,ZHIYOUDANGWOMENJINXINGGENGDUODEYANJIUZHENGSHIQIANQUANXINGHOU,CAINENGGOUYONGYUYANZHANGRENDESHOUMING”。SUIZHERENMENDUILEIPAMEISUJIQILEISIWUZUOYONGJIZHIHEBULIANGFANYINGDESHENRUYANJIU,zuiZHONGXUNZHAODAONENGGOUYANHUANSHUAILAO,TIGAOLAONIANRENSHENGHUOZHILIANGDEYAOWUKENENGBINGFEIYAOBUKEJI。

    LEIPAMEISUDASHIJI

足球竞猜软件    TORSHIXIANZAISHENGWUXUEDEYANJIUREDIAN,MEIGEYUEDOUYOUXINDEXUESHULUNWENYICIWEIZHUTI。

    LEIPAMEISUJIQIBABIAOTORDANBAIDEFAXIANDUIYUSHENGWUKEXUELAISHUOZHIGUANZHONGYAO,YEJIXUESHUJIEHEGONGYEJIEDEKEXUEJIAMENCHUANGZAOLEYIBICAIFUBAOZANG。KEXUEJIAMENSUIHOUKAIFALEXUDUOLEIPAMEISUDEBANHECHENGYANSHENGWU,BINGZAIHENDUOKANSIBUXIANGGANDEJIBINGZHILIAOLINGYUSHAIXUANQISHENGWUHUOXING。ZHEIXIEHUAHEWUFENZIYUJIBINGJIANDEXIANGHUZUOYONGZAILEIPAMEISUHETORDANBAIBEIFAXIANZHIQIANBINGBUWEIRENSUOZHI。

    ZHEIYEXUJIUSHILEIPAMEISUCHIXUJIYURENLEIDELIWU。

    FUHUOJIEDAOSHANGZHIJINZHULIZHEJINIANLEIPAMEISUFAXIANDEjiNIANBEI

 
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